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The aggregation factor noticeably influences the maximum transverse normal and the maximum hoop stresses developed in the cylinder.
In addition to size, aggregation factor of nanomaterials need to be considered sensibly; however, this phenomenon has frequently been overlooked, if not than considered trivial for many biological and medical applications, which is misleading.
Figures 3 and 4 also give the individual aggregation factor for each LC, and we note the large influence of supervising on the average aggregation factor, which increases from 2.46 to 8.92 (2.41 to 8.55 by using unsmoothed matrices), twice the effect compared with the 1993 94 training.
We show in METHODS how the matrix is calculated and how an aggregation factor can be defined for each LC6, which should be greater than one for a significant LC6 aggregation.
The relative very low aggregation factor of 1.5 in the supervised training, corresponds to the 74 days, along 1975 94, with LC = 10 or total undefined (UND) CWT (0,0,0), which cannot be properly normalized with KNN.
Choosing a large training period will include more 5BLC/BLC6 observed samples and, as we showed before, it will also increase the aggregation factor from unsupervised to supervised Kohonen maps.
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This article intends to discuss protein aggregation and its related mechanisms, methods characterizing protein aggregation, factors affecting protein aggregation, and possible venues in aggregation prevention/inhibition in various stages of protein drug development.
Linkages between soil structure and physical chemical soil properties are still poorly understood due to the wide size-range at which aggregation occurs and the variety of aggregation factors involved.
In summary, we propose a three-step strategy, using FTIR, SEC and DOE techniques, to effectively analyze the aggregation factors and perform a rapid screening for suitable conditions of protein formulation.
A simple systematic approach using Fourier transform infrared (FTIR) spectroscopy, size exclusion chromatography (SEC) and design of experiments (DOE) techniques was applied to the analysis of aggregation factors for protein formulations in stress and accelerated testings.
Besides the LC aggregation factors, the neighbourhood matrix gives more local valuable information.
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