I am quite confident because they are predicated on a massive aggregation of evidence of every description, spanning methods, populations, and decades.
The terminology surrounding the aggregation of evidence in a systematic way implies that there is a practical import to this work, and the terms "evidence-based practice" (EBP) and "evidence-based approaches" (EBA) have arisen from this concept.
The aggregation of evidence on barriers and facilitators to working collaboratively and experiences about the processes of collaboration is of value to understand success factors and factors that impede collaborative working relationships.
Nuclear environment has been shown to favor toxicity, pathology and aggregation as evidenced by nuclear targeting of polyQ peptides [26], even when inserted into ectopic protein contexts [27].
These experiments also revealed that thermal melting is irreversible, likely due to protein aggregation, as evidenced by the formation of a white precipitate upon denaturation.
Addition of glycerol on intact MDA-MB-231 or HCT116 cells prior to incubation at 42 °C also inhibited HS-induced c-FLIP aggregation as evidenced by the increase of c-FLIPL in the cytosolic fraction.
Since the two mutations significantly increased PrP aggregation, as evidenced above by protein chemistry studies, we asked whether there are any changes in organelles and cellular structures induced by mutant PrP that readily formed aggregates.
When Au nanorod-based SERS tags are prepared as we have described previously, the degree of aggregation, as evidenced by a red-shift in the extinction spectrum, can be affected by the acid washing step used to remove CTAB from the rod surface.
An adequate representation and a feasible aggregation procedure of evidence represents a challenging problem in many disciplines.
Observed familial aggregation together with evidence from both twin and epidemiological studies demonstrate a key role for inherited genetic variants [1].
