The phrase "aggregation and localization" is correct and usable in written English.
It can be used in contexts related to data processing, information management, or geographical analysis where combining data and determining specific locations are involved.
Example: "The project focuses on the aggregation and localization of user data to improve service delivery."
Alternatives: "collection and positioning" or "gathering and site-specific analysis".
Taking into account that mitochondria appear to respond to some viral infection by migrating with viral tegument proteins (Ohta and Nishiyama 2011), we suggest that these novel ORFs might have a role in the aggregation and localization of mitochondria, producing the aggregated and dispersed patterns of distribution of spermatozoon mitochondria observed in early DUI embryos.
For these reasons, QD could be an excellent tool for real-time monitoring of Aβ aggregation and localization.
IF staining showed aggregation and localization of Ang-2 in the cytoplasm suggesting WPB exocytosis within 30 minutes.
It is unlikely that repeat A contributes to aggregation and localization of Xist, since studies using constructs expressing a mutant form of Xist have shown that Xist localizes normally in the absence of the A-repeat, but lacks silencing activity (Royce-Tolland et al. 2010; Wutz et al. 2002).
To study the role of CC structures in the aggregation and localization of RUNX2 in vivo, we overexpressed GFP-tagged wt RUNX2 and its CC structural mutants in HEK293 cells and analyzed their subcellular distribution and aggregation state through confocal fluorescence microscopy and biochemical approaches (Figs 4 and 5).
To check whether MblC aggregation and subcellular localization depended on the amount of transfected plasmid or were cell-type specific, we transfected HEK293T cells with a third of the constructs used initially (Figure 4B ´).
The findings of HAMLET aggregation and its localization in lysosome-like structures prompted us to investigate the role of autophagy in HAMLET-induced cell death.
By point mutation, Havel et al. have demonstrated that Ser-16 is essential for both aggregation and nuclear localization, as phosphorylation reduces the affinity of the protein for nuclear pores, which are involved in the nuclear transport pathway.
The aggregation and co-localization of α-Syn with pGSK-3β and p-Tau was analyzed by immunohistochemical [IHC] staining of the striatum of A53T α-Syn mutant mice and compared to age-matched wild-type mice [Fig. 5A C].
SAS-6 aggregation after activation and localization at flagellum tips suggest a conserved BB location (Fig. 2) and fits with the structural defects found in the knockouts.
Here, we focused on the process regulating Fus and Tdp-43 localization and aggregation and showed that Oxr1-C restores nuclear localization of Fus and Tdp-43 mutants and reduces cytoplasmic aggregation through a pathway independent of proteasome- and autophagy-mediated degradation, but dependent on Prmt1-modulated arginine methylation.
