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In autophagy lysosomal pathway, p62 is an ubiquitin-binding scaffold protein that directly binds to LC3 to facilitate ubiquitinated protein aggregates degradation.
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Figure 6 Mechanisms of proteoglycan aggregate degradation.
The action of burnt oil shale was observed in concrete expansions and aggregate degradation by SEM.
The gap-graded asphalt mixture experienced a greater amount of aggregate degradation after compaction compared to the continuously graded mixture.
The results of aggregate degradation have been determined by comparing the aggregate gradation in terms of retained aggregate per individual sieve size before and after compaction.
The results show that asphalt mixture type and therefore aggregate gradation has a far greater influence on aggregate degradation under compaction than alterations to the level of compaction energy within the normal compaction levels experienced in the laboratory.
The effect of increased compaction energy level did not alter the pattern of aggregate degradation for the continuously graded asphalt mixture and only increased the degree of degradation by a small amount.
By analyzing the grading evolution during mixing, it was shown that both cleavage (creation of intermediate size particles) and attrition (creation of small particles) mechanisms influenced the aggregate degradation.
The addition of burnt oil shale allows the reduction of aggregate degradation and modifies gel products with a lower C/S and a mix of CSH and ettringite for the flint concrete.
The most severe form of laboratory compaction in terms of potential aggregate degradation, i.e. Marshall (impact) compaction has been used together with a standard UK aggregate and two asphalt mixture gradations consisting of a continuous and gap-graded mixture design.
Using an inhibitor of lysosomal degradation, bafilomycin A1, we thus tested if the decrease in aggregates observed with GSK3 activation in muscle cells was due to aggregate degradation via autophagy.
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