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Intracellular deposition of fibrillar aggregates characterizes several neurodegenerative diseases, but induction of intracellular fibril formation in vivo by exogenous agents is a rare finding, even though environmental factors are believed to play a major role in these complex disorders (Coppede et al. 2006).
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For water repellent aggregates, characterized by contact angles >40° and low water infiltration rates (<0.2 mm3 s−0.5), the fraction of disrupted aggregates after 30 s of immersion was generally below 10%, whereas in case of the more wettable aggregates, characterized by contact angles <10° and higher infiltration rates (>0.25 mores−0.5) more than 80% of the aggregates were disrupted.
Micelles formed in nonpolar solvents such as toluene have a hydrophobic corona and are referred to as 'reverse.' Recently, much attention has been devoted to highly asymmetric block copolymers that form aggregates characterized by a large core and a thin coronal shell of the soluble block: the crew-cut systems [79, 80].
Further, we used Aβ (1-40) fibrils, which are polypeptide aggregates, characterized by a fibrillar structure and the presence of a cross-β conformation [25].
Synovial inflammation was also quantified as the density of cellular infiltration by macrophages, T-cells, B-cells, or their organization into lymphoid aggregates characterized as lymphoid neogenesis (LN) as previously described (33).
Using different biophysical techniques we will show that both conditions promote the very rapid formation of aggregates, characterized by significant β-sheet structure but only weak ability to bind ThT and CR and a morphology different from that of regular amyloid fibrils.
The CD spectrum is highly similar to that of protein aggregates characterized elsewhere (Digambaranath et al., 2010 ).
Amyloid aggregates, characterized by displaying a core region formed of repetitive arrays of β-sheets oriented parallel to the fibril axis [ 5, 6], are the hallmark of increased number of human diseases ranking from AD to Creutzfeldt-Jakob disease (CJD) [ 7].
In contrast, ZnO aggregates were characterized by smaller fractal dimensions when ionic strength, and the resulting aggregation rate, were increased.
These aggregates were characterized and tested to see their suitability to be utilized in bituminous mixtures.
Polymers and their aggregates are characterized by NMR, dynamic light scattering, and electron microscopy.
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