Expanded CUG tracts form both nuclear and cytoplasmic aggregates, yet the relative significance of such aggregates in eliciting DM1 pathology is unclear.
If a group of monkeys occupies three widely separated trees, their spacing will obviously be aggregate; yet in each tree, their spacing may appear to be uniform.
Studies reporting on predictors of use almost always discuss CAM in the aggregate, yet each CAM modality represents a unique approach to healthcare, and each may have different correlates as well as different effectiveness.
It is not valid as an indicator in the study of regional aggregates, yet it serves to highlight our results regarding visibility.
Nobody has yet aggregated the number of these service providers, but I have no doubt it is already in the tens of thousands.
So the city of the future is actually here today, just not yet aggregated in one place nor designed and built by any one nation's innovators.
In NMR HSQC spectra, in the presence of a molar excess of Ub (i.e., a [Ub]:[Josephin] ratio of 3 1), a significant residual signal attributable to a fraction of soluble protein that has not yet aggregated is observed after 85 h at 38°C (corresponding to a half-life-time of 2174 min) (Fig. 4 A).
The mhtt concentration in our experiments was chosen to allow mhtt aggregation to occur in a reasonably short time in the absence of TRiC (Scherzinger et al., 1999), and the ratio of TRiC to mhtt was chosen to yield initial-stage fibril aggregates and yet thwart large-aggregate growth (Behrends et al., 2006).
The mhtt concentration in our experiments was chosen to allow mhtt aggregation to occur in a reasonably short time without TRiC (Scherzinger et al., 1999), and the ratio of TRiC to mhtt was chosen to yield initial-stage fibril aggregates and yet thwart large-aggregate growth (Behrends et al., 2006).
The model predicted the wild-type phenotype within 1%24%4% in vivo vs 25% in silico), yet it aggregated the partially and fully converted phenotypes observed in vivo (22% partial, 54% fully converted) into a single partial phenotype (75% partial).
