The phrase "aggregated defects" is correct and usable in written English.
It can be used in contexts related to quality control, manufacturing, or software development to refer to a collection or total of defects identified in a product or system.
Example: "The report highlighted the aggregated defects found during the testing phase, indicating areas that require immediate attention."
Alternatives: "combined defects" or "total defects".
The autophagic pathway has been shown to play a crucial role in the degradation of aggregated proteins, and defects in autophagic function, including the known decline in autophagy with aging, have been implicated in the pathogenesis of degenerative diseases (Rubinsztein et al., 2011).
The impact of aggregated PABPN1 on cellular defects is not fully understood.
Interestingly, many of the phenotypes were similar to those observed in sept9a morphants including cardiac and tail fin edema, a curved tail and/or body axis, a loss of circulating blood cells with concentrated pools of cells in the tail region and ICM, and epidermal defects including regions of aggregated cells (Fig. 4H, I).
Given these results, and the large overlap between proteins aggregating upon such diverse conditions as U34 modification defects and chaperone loss, we propose that many of the aggregated species abundant enough to be detected by mass spectrometry are metastable and thus highly vulnerable to perturbations in the cellular folding environment.
Thus, there appears to be a common final pathway for multiple forms of familial and sporadic ALS, wherein cytosolic accumulation of aggregated proteins, whether via a primary enhancement of aggregate formation or via defects in autophagy or the UPS, creates an environment that promotes neurodegeneration.
In cystic fibrosis, which is believed to arise as a result of mutations in this Cl−-HCO3− channel (De Braekeleer and Daigneault, 1992), defective secretion of HCO3− by enterocytes leads to defects in mucus secretion by the goblet cells, resulting in abnormally thick, aggregated, mucus (Garcia et al., 2009).
Obviously, neurodegenerative disorders interconnect several cellular signal transduction pathways to cause oxidative stress in the brain, including increased oxidative damage, impaired mitochondrial function, defects of the proteasome system, the presence of aggregated proteins, and many more [ 7].
Loss of Drosophila Usp36 (dUsp36) accompanied the accumulation of aggregated histone H2B (known substrate of Usp36) in cell nuclei, reflecting profound defects of chromatin structure in dUsp36 mutant cells.
These defects were supposed to originate from grain boundary regions and interfacial free volumes near aggregated β-As4S4 crystallites.
To further study the morphological defects of Rac1/Rac3-deficient interneurons and their intrinsic or extrinsic nature, we grew ventrally aggregated YFP+ cells from the MGE on collagen-coated coverslips.
