Compared with STIM2, binding of STIM1 K-rich domain to PI 4,5 P2 is restricted to conditions where STIM1 proteins aggregate as a consequence of Ca2+ depletion from the ER lumen.
This may be a consequence of G37R aggregating as a less toxic strain due to blocking formation or changing the structure of a β-strand III dependent aggregate.
As the force holding the monomers together is constant, aggregates break as a consequence of rotation when they exceed a certain size.
In this model, nuclear bodies are essentially dynamic protein aggregates which form as a consequence of multiple, transient interactions amongst a large number of proteins.
As a consequence, aggregating information across polymorphisms within a window of sites can provide a more accurate characterization of divergence.
This may lead to crack formation along the aggregate-paste interface and, as a consequence, to a lower tensile splitting strength (Nguyen et al. 2011).
I would prefer using them to, 1) Indemnify the bottom quintile of wage earners so that their net tax payments, in aggregate, do not increase as a consequence of the tax, 2) Provide some sort of job training or early retirement options for coal miners, and 3) Use the remainder to cut corporate income tax rates.
As a consequence, we aggregate the variance effects of genetic drift, sampling of individuals to bulks, and library construction events into a single quantity for each population: (1a) (1b) (1c) The population specific ν terms are common to all SNPs within each population.
As a matter of fact, the RCAs are composed of natural aggregates and attached mortar and, as a consequence, they generally present a higher porosity in comparison with ordinary natural aggregates.
As a consequence CD8lumenal, remained aggregated in the ER even during drug treatment.
