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While the present results do not support the idea of an integration window of fixed duration, it is possible that the aggregate time required for recognition varies as a function of the number of dots needed for recognition.
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The major benefit was a reduction in time from data collection to researchers and managers accessing the data, shortening the time required for aggregating, analyzing and reporting.
In contrast to this relatively rapid assembly, mature HTT exon1 amyloid requires about one month to dissociate in vitro, which is similar to the time required for neuronal HTT exon1 aggregates to disappear in vivo after HTT production is discontinued.
The long time required for scientific production, combined with the needs of decision-makers, led to the creation in 2010 of a project to support implementers in aggregating knowledge on their experiences.
Proteins that require chaperones have to be translated at a speed that fits the time required for chaperone recruitment (i.e., chaperone abundance and turnover rate), otherwise the protein will fold spontaneously into the wrong conformation, thereby forming aggregates that hinder the cell viability (Geiler-Samerotte et al. 2011).
Traditional surveillance approaches are expensive to maintain due to their use of survey interview methods for data collection and the time required to aggregate the data.
The more elements (e.g. IM) affected, the smaller the change in their aggregate activity required for system control.
RESULTS The time required to form aggregates was shorter in diabetic patients at shear rates below 200s−11 (P < 0.01).
In this study, the time required to reach the final diameter (TF) of the slump-flow test is correlated to dynamic segregation for mixes with a constant DF and aggregate-to-binder ratio.
The chaperone Hsp104 that helps to disassemble protein aggregates is strictly required for the cellular toxicity.
Mice lacking both p62 and Atg7 are free of aggregates, indicating that p62 is required for aggregate formation in autophagy-deficient states and that autophagy is responsible for the clearance of these aggregates (111, 116).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com