The phrase "aggregate spread" is correct and usable in written English.
It can be used in contexts related to finance, statistics, or data analysis, where it refers to the overall difference or variation across a set of data points or financial instruments.
Example: "The aggregate spread between the various bond yields indicates a significant shift in market sentiment."
Alternatives: "overall spread" or "total spread".
A previous study established an interplay between cell-cell and cell-substratum adhesion in mediating aggregate spreading [ 34] and it is likely that a similar relationship exists for aggregates of MLL cells.
This is the first demonstration that prostate cancer cells can vary in their ability to assemble a fibronectin matrix and that this correlates with aggregate cohesion, a property previously demonstrated to significantly influence cell detachment [ 3], aggregate spreading onto a substrate [ 34], and invasive capacity [ 1, 2, 32].
Thus, propagation of the pathology via neural pathways can potentially explain how α-syn aggregates spread in PD.
Some of them remained isolated as single cell aggregates, spreading limited cell extensions along radial directions.
In support of this idea, Takahashi and Kondo (Takahashi and Kondo, 2008) describe in regeneration experiments that melanophores in the absence of xanthophores do not aggregate but spread out into the available space, maximising their distance from each other.
These studies have suggested that tau aggregates, like extracellular amyloids [ 19, 43], can recruit monomeric tau into fibrillar aggregates that spread to neighbouring brain regions through an as yet unknown mechanism.
Furthermore, although most local surveillance data are aggregated, the spread of influenza likely varies according to population subgroup.
This diffusion of P42-TAT will help to provide better efficacy, preventing aggregate intercellular spreading for instance [ 39].
A view is developing, therefore, that just as mis-folded prion protein is able to convert normal soluble protein to the mis-folded state, then so might neurodegenerative aggregates also spread by intercellular transmission.
Several studies indicate that α-synucleinopathies as well as other protein aggregation diseases share key molecular features [ 29, 58] including aggregate toxicity and spread by seeded aggregation with prion disorders [ 1, 31].
