Sentence examples for aggregate pathology from inspiring English sources

Neuropathological studies implicate a spread of α-synuclein aggregate pathology [ 13] because in early stages the pathological changes are restricted to certain areas that are constantly involved in later stages.

We find an identical distribution in aggregate pathology between the R6/2 and HdhQ150 models, with only minor differences in aggregate abundance.

Furthermore, it prevented from α-synuclein toxicity in a transgenic fly model despite the continuous presence of aggregate pathology [53], [54]).

We have previously reported that polyQ aggregate pathology, in the form of nuclear inclusions, is also present in a wide range of peripheral tissues in the R6/2 mouse [15] including skeletal muscle and pancreatic islets.

To begin to determine whether the peripheral aggregate pathology present in the R6/2 mice has relevance for the human disease, we have conducted a comprehensive investigation of the distribution of polyQ aggregates in the peripheral tissues of the HdhQ150 knock-in model expressing mutant full length Htt at endogenous levels.

The aggregate pathology in the R6/2 mice occurs throughout the brain and in many peripheral tissues.

Mixed-aggregate pathology and synergistic injury underscore the relevance of therapeutics capable of targeting both α-syn and tau.

In aggregate, synaptic pathology, rather than neurofibrillary tangles and plaques, represents the main correlate of cerebellar degeneration in AD.

More importantly, acceleration of lipid raft aggregation leads to disease advancement, whereas disruption of the aggregates delays pathology [ 9].

If this is the case, then it will always be challenging to link the aggregate to downstream pathology through cross-sectional analyses.

For example, a motivating use case amongst prospective adopters is to aggregate treatment, endpoint, pathology, and tissue banking data from a number of different cancer centers.