Traditional genome-wide association studies (GWAS) test one single nucleotide polymorphism (SNP) at a time for association with disease, overlooking interplay between SNPs within a gene or pathway, missing weak signal that aggregates in sets of related SNPs and incurring a severe penalty for multiple testing.
The deficiency or the mutation of related genes leads to abnormal protein aggregates, immunity deficiency, and oncogenesis.
Given that discrepancies between meta-analyses and the 'truth' occur frequently [ 39, 40], circumspect interpretation of these aggregate data related to the incidence of pneumonia is recommended.
Using the Peruvian National Skills and Labor Market Survey, they find that Openness and Emotional Stability are related to wages, and that an aggregate of these two plasticity is related to employment.
The number of colonies formed after the injection of aggregates was related to aggregate size and was proportional to the number injected.
Series of tests are conducted on road construction aggregates, not only for selection of appropriate aggregate which meets related specifications, but also for estimation of the long-term performance of aggregates particularly for economic and safety reasons.
With regard to GxTDEE and GxDEE interactions, the fundamental null hypothesis is that the expression of a polygenotype (i.e., aggregate of all genotypes related to the expression of a phenotype) is independent of TDEE and/or DEE levels.
The changes in the morphology of the aggregates are related to the higher degree of ionization of poly acrylic acid) blocks at high pH and to the swelling of the corona of the micelles by the higher osmotic pressure due to trapped counterions.
A precise overview of the number of entrepreneurs, companies and personnel that provide health care services is not available from public sources; the Republic Statistical Office publishes aggregate data related to the activity of 'health and social work' but this is not precise enough to use.
The degree of mechanical interlocking and internal stress concentration around the aggregate, related to the aggregate surface characteristics, has a significant influence on microcracking behaviour of concrete.
