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Management now expects the aggregate conversion rate to move up by about 30%.
Third, surfactant may be deactivated by large alveolar surface area oscillations that stress surfactant adsorption and desorption kinetics and are associated with surfactant aggregate conversion.
In addition, a pronounced large to small aggregate conversion was observed for BALF from LPS-challenged mice or BALF from ARDS patients.
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The aggregate structure conversion in different molecular structures can be controlled in the form of sphere-like, rod-like, and vesicle-like structures.
We do not observe significant dimer-to-aggregate inter-conversion at room temperature, in agreement with the observation that no aggregation was detected by CD and NMR for the same constructs over a period of months [25].
The isolated aggregates acted as dose-dependent nucleation templates ("on-pathway" aggregates), because the conversion of monomeric aSyn into amyloid was significantly enhanced as the SERF1a:aSyn ratio was increased, and the initial lag phase was visibly reduced.
Significantly, amyloid or amyloid-like protein aggregates catalyze the structural conversion of the normally folded protein into additional aggregates via a seeded nucleation-dependent process.
However, this effect was achieved by conversion of aggregates to the molecular form of the conjugated polymer.
Possibly basement membrane components, such as laminin or glucosaminoglycans, might bind small diffusible PrPres oligomers found in the extracellular fluid causing these oligomers to be concentrated and possibly assembled in ordered aggregates, thus facilitating their conversion to PrPres.
In particular, as far as the latter are concerned, the molecular events that lead to the conversion of reversibly aggregated oligomers into stably aggregated fibrils are still largely obscure.
UB "Provides a native shopping basket for apps that aggregate products, significantly increasing their conversion rate".
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