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The oxidized SOD1 including Cys-SO3H tends to misfold and aggregate, a characteristic relevant to the pathology of ALS [ 8, 17].
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Direct misexpression of wild-type human tau in the fly retina resulted in early onset cell death in the larval eye disc, as evidenced by the formation of lamin-containing aggregates, a characteristic of caspase-dependent cell death (21).
In vitro experiments demonstrated that FGF rather than TGF or EGF induced the endothelial cells (derived from the epiblasts) to aggregate into a characteristic vascular structure (Flamme and Risau, 1992).
The MM1-4 culturestures described here are able to engraft after pseudo orthotopic intraperitoneal transplantation in immunodeficient mouse, where they mainly grow as free floating cells that eventually aggregate, recapitulating a characteristic that is thought to be typical of normal mesothelial stem/progenitor cells [ 22].
The results show that asphalt gradation and aggregate characteristics can significantly impact the anti-skid performance of the asphalt pavements; grinding and kneading will lower the indices, including the fractal dimension, average depth, number of peaks and friction coefficient of both the aggregate and track board; asphalt pavements of aggregate A and a design gradation of GAC are adopted.
Rather loose and hydrated polymeric aggregates with a characteristic hydrophobic multicore structure, achieved by the first-stage thermally induced phase transition of PNIPAAm grafts, underwent the core structure rearrangement (including multicore fragmentation and fusion) upon the second-stage dehydration of mPEG grafts at 90 °C.
Following nucleation, short polymeric aggregates with a characteristic "beaded" structure emerged (Fig. 1 B).
As our studies in cultured cell lines and primary motor neurons indicated that Met-TDP-35 formed cytoplasmic aggregates, recapitulating a characteristic feature of TDP-43 proteinopathy, we proceeded to assess the pathological relevance of Met-TDP-35 in ALS disease tissues.
Since the voids in porous concrete are mainly formed by coarse aggregates, a morphological characteristic of the aggregate is deemed most important, and need to be of uniform size, rough surface, and low specific gravity (Jang et al. 2015a).
In some instances, the fungus infecting the plant may produce growth or structures on the plant, stems, or leaves such as masses of mycelium or aggregates of spores with a characteristic appearance.
However, despite possessing non-connected boundaries (a characteristic of object aggregates, see table 1), an aggregate of objects and fiat object parts is not a mereological sum exclusively composed of separate object entities.
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