Frovatriptan was chosen mainly because of the rapid onset of action (54.1% of patients), reduction in pain severity (13.5%), and prevention of aggravation (13.5%).
The most common reasons for preferring one triptan were the rapid action (51.4% frovatriptan and 55.0% almotriptan), prevention of aggravation (13.5% and 2.5%), and reduction of severity (13.5% and 15.0%): no significant differences were observed between treatments for these data.
Two retrospective studies reported that 24 35% of women with migraine experienced an aggravation, 5% an improvement and 44 65% no change in their migraine during treatment with contraceptive pills [79].
The link between vitamin D and SLE is two sided (Fig. 1); so that, SLE may lead to lower vitamin D levels and vitamin D deficiency may have a causative role in SLE etiology and/or aggravation [6].
As another hypothesis, the stretch of the atrial septum caused by the device itself might induce the release of the atrial natriuretic peptide (ANP) from the atrial myocytes, a vasoactive antagonist of vasopressin that has been proposed as a possible link between ASD closure and migraine aggravation [5, 6].
Of the readmissions, 54 (30%) were caused by HF aggravation, 35 (20%) had other cardiovascular causes, and 27 (15%) had noncardiovascular causes.
In the elderly group, 72 patients (73%) were hospitalized: 40 (41%) due to HF aggravation; 12 (12%) due to other cardiovascular causes; and 20 (20%) due to noncardiovascular causes.
The presence of nucleotide substitution was compared between 2 groups of patients: 1 with good prognosis (absence of pulmonary aggravation; n = 25) and 1 with adverse outcome (pulmonary aggravation 8 12 days after onset of symptoms requiring oxygen ventilation or transfer to ICU; n = 4).
In the nonelderly group, 44 (55%) of the patients were hospitalized during the 1-year follow-up: 14 (18%) due to HF aggravation; 23 (28%) due to other cardiovascular causes; and seven (9%) due to noncardiovascular causes (Table 2).
Also, as pointed out by Ben-Ari et al., the earlier administration of bumetanide may help to ameliorate the eventual down-regulation of KCC2 and possible seizure aggravation, 32 which take place after an initial functional up-regulation of KCC2 by neonatal seizures.
The subscales measure the degree to which patients agree that they have been prevented from carrying out the intervention due to: (1) symptom severity or aggravation, (2) uncertainty regarding how to carry out the treatment, (3) doubts about treatment efficacy and (4) practical problems such as lack of time.
