Sentence examples for aggravating interaction from inspiring English sources

The scoring functions were also shown to be specific to the alleviating and aggravating interaction classes (Additional File 1).

Thus, we interpret the aggravating interaction between CHL1 and BUB3 as resulting from unidirectional compensation, where CHL1 is the upstream gene and BUB3 is the downstream gene (Fig. 6).

Genome-wide genetic screens of rbbA and yhjD displayed aggravating interactions with members of the electron transport chain (ETC).

Epistasis refers to the phenomenon in which the phenotypic consequence of altering one gene is differentially modulated by the specific alleles of a second one, including both negative (aggravating) interactions and buffering (relieving) interactions [21].

Red arrows depict aggravating interactions and blue arrows depict alleviating interactions.

However, in many cases this explanation cannot account for the observed patterns of aggravating interactions and the large number of such interactions between genes with distantly related functions.

Aggravating interactions are commonly interpreted as an indication of bidirectional compensation, where each gene can compensate for the absence of the other by performing a similar function.

For example, aggravating interactions, which occur when the phenotypic impact of the double deletion is greater than predicted by neutrality, may result from the loss of compensatory pathways.

In contrast, mutants of both RPE1 and TKL1 shared aggravating interactions with mutants of IRA2, SSD1, PPZ1, HOG1, and PBS2, indicating that they buffer glyoxal resistance via distinct pathways.

The reasoning we outline here (and apply below) detects, up to usual concerns about experimental or statistical noise, asymmetries of aggravating interactions with respect to phenotypes of external stimuli.

In a similar manner, each gene deletion defines a list of genes that are sensitive to its deletion, i.e. display aggravating interactions with it using the same threshold, −2.5, as Collins et al. 2007a; Schuldiner et al., 2005).