The phrase "aggravated development" is not commonly used in written English and may lead to confusion.
It could be used in contexts discussing negative or problematic growth, but it is not a standard expression.
Example: "The project faced aggravated development issues due to lack of funding and poor management."
Alternatives: "problematic development" or "challenging development".
Trapezius myalgia has also been associated with an inability to properly relax the muscle between repeated contractions [ 23], which may aggravate development of fatigue.
But with the increase in the pozzolanic reaction, the self desiccation effect coupled with the increase in disjoining pressure could probably have aggravated the development of micro cracks.
The presence of coccidia might have aggravated the development of lesions in the bursa caused by IBDV.
We demonstrate that lack of sclerostin aggravated the development of OA in mice submitted to joint instability as a result of disrupted anabolic/catabolic balance.
Neither smoking nor nicotine exposure aggravates development of CII-induced arthritis in mouse model.
IL-17 and IL-22 play a dual role: on the one hand, they stimulate the epithelium to produce antimicrobial peptides and proteins, and mucus-associated molecules to clear the pathogen and tumor cells to maintain homeostasis of the mucosa; on the other hand, they may aggravate the development of obesity-related asthma and COPD.
Dyslipidemia in combination with inflammation initiates and aggravates the development of atherosclerosis and CAD [ 1].
Diet, particularly dietary glycemic index, saturated fat, trans fat, milk, and fish may influence or aggravate acne development [ 9].
In this chronic phase, the enhanced uptake of both RBCs and iron-containing compounds is maintained, which aggravates anemia development [ 125].
We know that bacterial infections may serve as environmental triggers for the development or exacerbation of SLE in genetically predisposed individuals [ 43], and that bacterial LPS plays an important role in the pathogenesis of SLE, such as, it could aggravate disease development by activating proliferation of B cells, production of autoantibodies and proinflammatory cytokines [ 44, 45].
