The phrase "aggravate over time" is correct and usable in written English.
It can be used to describe a situation or condition that worsens or becomes more severe as time passes.
Example: "If left untreated, the patient's condition may aggravate over time, leading to more serious health issues."
Alternatives: "worsen over time" or "deteriorate as time goes on."
Inundations across SCD generally vary as a function of storm intensity, but for lowlands or regions without drainage facilities inundations tend to aggravate over time.
If, however, myosin Va facilitated recycling of endocytosed AChRs towards the NMJ, blockage of the motor protein would be expected to diminish NMJ size; furthermore, if there were multiple rounds of AChR recycling one would anticipate that the loss of AChRs should aggravate over time.
While there are no laboratory studies investigating the hemostatic status of patients 5 10 years after their OLT, it is plausible that the hemostatic abnormalities induced by immunosuppressive drugs described in this study persist or even aggravate over time.
Global warming issue, which increasingly aggravates over time, necessitates the carbon capture and storage (CCS) technology for its efficient mitigation.
This experimental study demonstrated that CsA-induced nephrotoxicity is significantly aggravated over time and distinct mechanisms seem to underlie short- and long-term renal toxicity.
In contrast, quantitative analyses of vessel branching points revealed a defect from E13.5 onwards that aggravated over time, such that at E14.5, the VT of Tgfbr2-cKO contained significantly fewer vessels (Fig. 1E, Supplementary Material, Fig. S5Cc, d, S5Dc, d).
This may be related to the relative stability of the glucokinase-related β-cell defect, as insulin secretion in MODY2 subjects does not seem to aggravate substantially over time.
"People change over time.
Progressive cardiac hypertrophy (Limongelli et al, 2010) in these primary mitochondrial diseases might be therefore explained as follows: Primary mitochondrial respiratory impairment can initially be compensated for, but over time is aggravated by secondary stochastic mitochondrial damage.
Shoes that are too narrow can aggravate bone spurs that have developed over time on the foot causing blisters and corns to form.
Concerns about the emergence of inferior leadership over time are further aggravated when the dual-class structure enables a transfer of the founder's lock on control to an heir who might be unfit to lead the company.
