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Indeed, the incorrect dose can prime the immune response and aggravate disease.
However, institution at late time-point appeared to aggravate disease [ 95].
If these microbes aggravate disease by superimposed infection, antimicrobial therapy would be predicted to halt disease progression.
Genetic ablation or neutralization of IL-17 can actually aggravate disease progress in dextran-sulphate-sodium-induced colitis in mice.
A clinical trial of an 'altered peptide ligand' of MBP83 99 was designed to inhibit MS but instead appeared to aggravate disease.
In most autoimmune disease models, ICOS blockade suppresses disease activity [ 62, 63], but it can also aggravate disease when it is given during the induction rather than the effector stage [ 64].
Similar(49)
In other words, generalized inflammation that damages blood vessels can potentiate or aggravate diseases such as atherosclerosis and stroke.
For instance, in glia, NF-κB is inducible and mediates inflammatory responses that aggravate diseases such as ischemia, autoimmune encephalomyelitis and Alzheimer's disease [ 39, 40].
Malnutrition aggravated disease, and many died.
Unexpectedly, mice lacking DCs developed aggravated disease compared to control mice.
Vascular endothelial growth factor-A (VEGF) typically induces abnormal angiogenesis in the adult, thereby aggravating disease pathology and limiting utility of VEGF for therapeutic angiogenesis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com