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This indicates a further potential for epigenetic targeting agents to alter the expression of a critical master regulator of immunity.
Alcohol is fast emerging as one of the chief agents to alter the epigenome of cells and tissues throughout the organism.
(As for the ability of some environmental agents to alter DNA, he was certainly aware, for instance, that mutagens can do so).
These collective observations underscore the importance of assessing the impact of sequencing when combining mTOR inhibitors with genotoxic agents, especially with regard to the relative impact of these agents to alter cell cycle inhibition.
However, few studies have investigated differences in the tumor microenvironment between ectopic and orthotropic xenografts and there are limited data on the effect of chemotherapeutic agents to alter tumor vasculature in these models.
A fuller discussion of receptor-mediated biology and toxicology (e.g. dose-response, potency, receptor occupancy and affinity) is needed, as this ought to be a key aspect of an evaluation of the ability of small exposures to environmental agents to alter and disrupt normal hormonal control processes (Borgert et al., 2012).
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Election control encompasses attempts from an external agent to alter the structure of an election in order to change its outcome.
Plasma treatment may be utilized as an agent to alter a surface's properties in a variety of ways.
The ability of a pharmacological agent to alter CSF absorption was related to the steady-state intracranial pressure (ICP), the concentration and the class of pharmacological agent delivered.
The ability of a pharmacological agent to alter CSF absorption was related to the steady-state ICP, and the concentration and class of pharmacological agent delivered.
As the effectiveness of immunotherapy may be limited by systemic and local tumour-induced immunosuppression, it is becoming more widely accepted that successful treatments will require a second agent to alter the tumour microenvironment and/or decrease immune suppression (Pardoll and Drake, 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com