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A chief limitation is the slow read time between measurements and the sensitivity of the sensor, resulting in difficulty with fast desensitizing receptor systems; yet with the judicious use of agents that maintain an active state and retard desensitization, this obstacle may be overcome and a suitable rank ordering of potency determined for agonists and antagonists.
Several candidate microbicides such as vaginal acid-buffering agents that maintain a protective vaginal pH, antiretroviral drugs specific for HIV, inhibitors of viral entry into animal cells and detergents or surfactants have been proposed and some of them are being tested in pre-clinical studies [1].
As agents that maintain HA homeostasis, hyaluronidase inhibitors may serve as anti-aging, anti-inflammatory, and anti-microbial agents.
Inhibitors of hyaluronidase are potent agents that maintain hyaluronic acid homeostasis and may serve as anti-aging, anti-inflammatory, and anti-microbial agents.
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For multi-drug resistant inpatient and outpatient MRSA alike there are relatively few agents that maintained high levels of activity (Table 4).
When given as an intravenous bolus to rats, methoxycarbonyl etomidate is an extremely short-acting hypnotic agent that maintains hemodynamic stability and does not produce prolonged adrenocortical suppression [ 11].
Another possibility would be to combine a cell-based Treg therapy with a biologic agent that maintains the desired functional state of Tregs (Tang et al., 2008), or which antagonizes the development of T-effector cells, perhaps by interfering with the IL-6 pathway (Fig. 3C).
Based on these results, antidiabetic agents that preserve, maintain, or improve β-cell function, such as exogenous insulin, glucagon-like peptide 1 analogs, dipeptidyl-peptidase 4 inhibitors, and thiazolidinediones (39), may merit attention for the vulnerable (40) transplant population and early posttransplant period.
Other indemnified companies include Mason and Hanger, a company which stores and transports containers of the nerve agent VX, and several firms that maintain facilities to destroy chemical agents.
However, the utility of these agents is limited to tumours that maintain a functional p53 pathway, a significant restriction given that p53 is often inactivated by mutations.
Next, a reinforcement learning agent transforms these paths into trajectories that maintain the bound on the load displacement while following the collision-free path in a timely manner.
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