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Large, ongoing clinical trials with these agents should provide insight into this question.
If an upregulated MAPK pathway is in fact the most important mechanism that drives tumor proliferation in melanomas carrying the BRAFV600E mutation, the high selectivity and potency of these new agents should provide more insight into the role of BRAF as a critical therapeutic target in melanoma.
The study of the mechanisms underlying the adaptive responses of cells to oxidising agents should provide clues to understanding the promotion and progression of such disorders.
Hence, the influenza virus recognition through immunomodulatory and anti-inflammatory agents should provide clues to making more effective therapeutics agents against influenza.
On the other hand, mobilizing endogenous NPCs by pharmacological agents should provide an alternative cell therapy for neurodegeneration (Miller & Kaplan, 2012).
Since DPP-4 inhibitors and metformin improve glycemic control via different, albeit potentially complementary, mechanisms, combination therapy with these two agents should provide effective and potentially additive glycemic control.
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These morphologies indicate that Sb nanotube can be formed through the rolling up of regularly ordered molecular layers during the solvothermal treatment process, in which toluene as a solvent plays the role of a structure-directing agent and should provide a possible driving force to facilitate the rolling of lamellar structures at 200 °C for 10 h [20].
Consequently, broad-spectrum antibiotics have been recommended, and the agent selected should provide coverage against the micro-organisms that are usually involved in the suspected focus of infection [ 35].
New developments in small-animal CT [ 172– 177] and the use of new contrast agents for CT should provide better image quality at lower radiation doses and/or with lower volumes of contrast agent.
Taken together, treatment of sublethal doses of DNA-damaging agents (Supplementary Figure 9) should provide us a good system to study autophagy-mediated non-apoptotic cell death.
Modified versions of these surrogates should provide agents capable of modifying the activity of these targets and enable one to study their involvement in specific biological processes as a means of target validation for downstream drug discovery.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com