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Such compounds may be useful for the design of antifungal agents possessing a new mechanism of action.
Since the influenza viruses can rapidly evolve, it is urgently required to develop novel anti-influenza agents possessing a novel mechanism of action.
Since fluconazole showed poor efficacy against aspergillosis, this compound was further optimized in the development of next-generation agents possessing a broader spectrum of antifungal activity, particularly for use against aspergillus infections.
With the current rapid growth of hybrid PET/MRI systems in diagnostic radiology, our molecular design of dual-modality agents possessing a "single pharmacological behavior" offers a versatile platform for the development of multimodality imaging agents with potential applications for noninvasive molecular profiling of various diseases.
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Adenoviral (Ad) vectors are useful gene delivery vehicles for this approach; however, because these agents possess a high natural tropism for the liver, systems must be designed to avoid potential hepatotoxicity induced by expression of the therapeutic gene in this organ.
This lack of elimination of bactericidal action suggests that these agents possess a secondary bactericidal mechanism of action that does not depend on the synthesis of protein and RNA, and that may be active when the bacteria are in a nonreplicating state (46 ).
He claims that this conception of rationality is implied by the fact that decision theorists are able to represent the rational actions of any agent possessing a well-behaved preference ordering as the maximization of a utility function.
This agent possesses a migratory capability and it is able to visit a set of nodes while maintaining its present information state.
Sorensen distinguishes between cases in which Effort Required is low because the agent possesses a "naturally good character" and those in which Effort Required is low because the agent has exerted effort to develop a character that makes morally desirable actions easy (p. 103).
Each agent possesses an inventory of names or words (i.e., opinions), which is initially empty.
Beta-propiolactone-induced rat nasal carcinomas contain a novel oncogene, 6 to 9 kb in size, whereas a mouse skin carcinoma induced by this agent possesses an H-ras oncogene activated by a 61st codon A to T transversion mutation.
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