In the social causation theory, the socio-environmental factors associated with low socio-economic status (including more life events stressors, increased exposure to environmental and occupational hazards and infectious agents, poorer prenatal care and fewer support resources if stress does occur) are a cause of schizophrenia [ 26].
Other factors may include availability of the suboptimal quality or substandard antimicrobial drugs, increased usage of a particular antimicrobial agent, poor sanitation, contaminated food and cross-contamination from humans or animals [ 36, 37].
From a clinical point of view, it would be interesting to quantify the impact of some determinants on severe decline and certain drop of kidney function, especially those which are manageable, such as nephrotoxic agents, infections, poor cardiovascular conditions and poor glucose control.
Our study has some limitations, including its small sample size, the heterogeneity of the antidiabetic agents used, poor glycemic control at baseline, and a short period of intervention.
As the Syrian blogger Anas Qtiesh writes, "These accounts were believed to be manned by Syrian mokhabarat (intelligence) agents with poor command of both written Arabic and English, and an endless arsenal of bite and insults".
Roth concluded that both agents "displayed poor judgment and a lack of institutional awareness" and "more likely than not both Connolly and Ogilvie's judgment was impaired by alcohol".
Throw in shoddy living conditions (according to the latest English housing survey, three out of 10 houses fail to meet the government's decent homes standard), dodgy letting agents and poor regulation, and the future looks pretty bleak.
Most of the conventional chemotherapeutic agents have poor pharmacokinetics profiles and are distributed non-specifically in the body leading to systemic toxicity associated with serious side effects.
Aiming at high salinity reservoirs, we overcame the weak point of conventional foaming agents with poor ability to salinity tolerance, and developed foam agents with excellent performances by compounding.
Drug or gene delivery based on nanostructure is promising for treatments of cancers to solve a variety of issues associated with traditional therapeutic agents from poor bioavailability to systemic toxicity.
