Sunitinib did not demonstrate a clinically meaningful single-agent objective response rate for patients with colorectal cancer refractory to standard chemotherapy.
For example, two small studies using MEK inhibitors have shown single-agent objective responses and promising survival (Bekaii-Saab et al, 2011; Finn et al, 2012).
In contrast, when patients in whom the tumour does not express the relevant target are treated with a molecularly targeted agent, objective response rates are notably disappointing.
For these agents, the objective response rates are generally modest, ranging from 15%to50%0%.
We consider the problem of designing truthful mechanisms for scheduling selfish tasks (or agents)—whose objective is the minimization of their completion times on parallel identical machines in order to minimize the makespan.
Both agents produce objective response rates in 20 to 30% of patients with HER2-positive metastatic breast cancer.
Changes in specific desired behaviors of the risk group or environmental agents (performance objectives) and changes in determinants (change objectives) are defined, based upon scientific analyses of (health) problems and problem causing factors.
Have data fused : once the agent knows the inertial data, the agent's objective becomes its fusion.
Independence in the formulation of public health policies can be affected by various agents with objectives contrary to population health, such as large corporations.
But she also stresses how the more interior and elusive powers of temperament and emotion can color noetic judgment and block the agent from objective perception of the external world.
