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Tumor hypoxia and overexpression of HIF1 have been associated with therapeutic resistance to anticancer agents, increase in invasion, metastasis and poor outcome in malignancies.
The claims-based effectiveness algorithm incorporated biologic dose escalation or switching, addition of new disease-modifying agents, increase in oral glucocorticoid use and dose as well as parenteral glucocorticoid injections.
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Subsequently, the therapeutically available concentrations of certain agents increased in BCRP knock-out animal models that were highly prone to Mitoxantrone induced toxicity [17].
These perspectives are vital to tackling our most urgent global health challenges, including the emergence of new infectious agents, increases in autoimmune diseases, the obesity epidemic, and threats to food safety and nutritional needs of growing populations.
With the exception of amikacin, the rates of resistance to the other tested antimicrobial agents increased in 2012.
The use of beta-blocking agents increased in intervention patients with CHD (+6.1%-units, OR 1.39; 0.99, 1.96, p = 0.06).
DOC is a natural endogenous agent increased in the colonic contents of humans in response to a high fat diet.
This study assesses whether ovulation induction agents increase DNA damage in the lymphocytes of infertile women undergoing superovulation.
On autopsy, some cases had undiagnosed congenital heart disease, which renders patients vulnerable to the effects of sympathomimetic amines (such agents increase contractility and, in turn, blood pressure).
Imaging with hepatocellular agents increases confidence in making the radiologic diagnosis, thus avoiding invasive biopsy.
Therefore, tubulin-depolymerizing agents increase the level of soluble tubulin in the supernatant whereas tubulin-polymerizing agents increase the insoluble tubulin in the pellet [ 14].
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CEO of Professional Science Editing for Scientists @ prosciediting.com