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However, glucocorticosteroids and antibiotics represent powerful pharmaceutical agents for which we have little knowledge regarding patient exposure and absorption.
We identify one class of agents for which a static linear protocol can be designed, which is named squared-down passifiable via input feedforward.
Another major advance in the care of brain metastases has been the advent of new immunotherapeutic agents, for which initial studies have shown intracranial activity.
This includes novel drugs designed to be veterinary therapeutics, as well as agents for which data generated in animals with tumors may inform human clinical trial design and implementation.
Although a third of patients remain resistant to treatment, the availability of more than 20 approved antiepileptic drugs can reduce the incentive to enrol in trials of unproven agents, for which safety is not assured.
Historically, epidemics or pandemics with high mortalities have been documented when humans interact with new agents for which they have no immunity, such as with Yersinia pestis (plague) in the Middle Ages and the introduction of smallpox and measles into the Americas after the arrival of Europeans.
Over the last decade, the focus of anticancer drug development has shifted from empirical cytotoxic chemotherapy to mechanism-defined molecularly targeted agents, for which appropriate patient selection at the earliest possible point in drug development is rational and critical to success.
The development of mucosal vaccines is crucial to efficiently control infectious agents for which mucosae are the primary site of entry.
In contrast, for highly transmissible pathogenic agents for which the immune response requires regular boosts to remain efficient, avoiding infections may be counter-productive and actually increases the deleterious impact of the pathogenic agent.
The large seal and mouse populations on Marion Island [6], [22] are likely to facilitate transmission of this virus and other infectious agents, for which Mus are reservoir hosts.
