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The NTP's nominations process, by which federal and nongovernmental entities can recommend agents for testing, was made clearer and more open to public scrutiny.
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Both the inferred information and the fused data are then aggregated and sent to the Anomaly Detector agent for testing the presence of anomalous data.
This study was conducted when very few novel agents were available for testing as single agent therapy.
This methodology is a new one, which gives the basic approach to agent-based frameworks for testing.
The most widely used preclinical models for testing agents for the treatment of cancer are xenograft models.
This model has been demonstrated to be suitable for studying the pathophysiology of type 2 diabetes as well as for testing agents for the treatment of type 2 diabetes in several studies [ 16, 33, 34].
Yet flumazenil has also been described as an anxiogenic agent for testing in the elevated plus-maze [66], [67], the social interaction model [68], [69] and the mouse defence test battery [58], [70]; it has been shown to produce an inverse agonist-like promnesic effect in a learning task [71].
Eculizumab, a Food and Drug Administration approved therapeutic antibody blocking C5 activation, could be a promising agent for testing in randomized clinical trials.
Although there is clinical relevance for testing reversal agents in a trauma model, all agents were administered ex vivo.
Orthotopic mouse models of human gastric cancer represent an important in vivo tool for testing chemotherapeutic agents and for studying intraluminal factors.
These data set the stage for future generation of orthotopic xenografts of primary human neuroblastoma and for testing new agents for this devastating childhood cancer.
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