Sentence examples for agents based upon from inspiring English sources
Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized.
This structural information could play an important role in the design of therapeutic agents based upon GIP receptor agonists.
This structural information will facilitate the design of novel therapeutic agents based upon the ranatuerin-2CSa structure with improved antimicrobial potencies but decreased cytolytic activities against mammalian cells.
Research laboratories around the world are currently focusing their efforts toward the development of radiometallated, site-directed, diagnostic/therapeutic agents based upon small peptides such as octreotide, neurotensin, α-melanocyte stimulating hormone, vasointestinal peptide and others.
Design of clinically valuable antibacterial agents based upon naturally occurring peptides requires the use of spectroscopic methods, particularly NMR, to determine the three-dimensional structure of the native peptide so that analogues with improved therapeutic properties can be made.
Here we describe the development of a set of antidote molecules that are capable of counteracting the effects of an entire class of therapeutic agents based upon aptamers.
The design of these agents was based upon energy minimization and structural overlay studies of the generic azepin-2-one structure 3 with the crystal structure of arylacetamide κ agonist 1, ICI 199441.
Empirical choices of antimicrobial agents are based upon the risk assessment of involvement of resistant pathogens.
Moreover, current data on the safety profile of pharmacologic agents are based upon small non-randomized studies, which therefore calls for larger randomized trials.
Continued efforts in our laboratory are focused on expanding a novel class of microtubule (MT -modulating anticancer agents, noscapinoids, based upon the founding MT -modulatinganticancer
Most of the available clinical information on histoplasmosis in patients receiving anti-TNF agents is based upon case reports and small case series, with the largest report a literature review of fungal infections complicating anti-TNF therapy [ 8].
