Our next studies are aimed at defining a 'good risk' group of patients, who may be curable without alkylating agents and a 'poor risk' group, who need more intensive therapy.
3, 4 A limited number of patients may benefit from chemotherapy but it is not possible to give chemotherapy with obstructive jaundice due to the hepatic metabolism of many chemotherapeutic agents and the poor performance status of a significant proportion of patients.
The resistance of cancer cells to chemotherapeutic agents and the poor selectivity of drugs toward tumor cells are regarded as the main impediments in successful cancer therapy.
The most common reasons for AKI after liver transplantation are ischaemia-induced acute tubular necrosis, nephrotoxic drug reactions especially due to immunosuppressive agents, a pre-existing hepatorenal syndrome and a poor preoperative condition of the patient [ 88].
However, because of a lack of specific imaging agents, there is a poor understanding of their absolute numbers, flux rates and functional states in different tissues.
Most of these studies have shown that TUBB3 expression is associated with resistance to tubulin binding agents, a poor prognosis, or both [ 17].
Many opposition members contended Monday that Hezbollah's Beirut rally was populated mostly by Syrian intelligence agents and poor Shiites from the south.
Throw in shoddy living conditions (according to the latest English housing survey, three out of 10 houses fail to meet the government's decent homes standard), dodgy letting agents and poor regulation, and the future looks pretty bleak.
Changes in p53 status have been linked to disease progression, decreased sensitivity to chemotherapeutic agents and poor prognosis (Cabelguenne et al, 2000).
Further, all these agents had a poorer side-effect profile compared to sorafenib.
