The phrase "agents a significant" is not correct in written English as it lacks grammatical structure and clarity.
It cannot be used in its current form due to the missing context and grammatical errors.
Example: "The agents play a significant role in the success of the project."
Alternatives: "agents play an important" or "agents have a major".
Although this leaves agents a significant range of freedom of action, it leaves them little security in their plans of action.
Despite some evidence of improved responses to novel agents, a significant unmet need remains for such patients.
Although we could not find significant differences to predict the response to these agents, a significant association for PFS in patients with low miRNA-143 expression was identified.
Finally, we tested the effectiveness of similar combinations of topical antibiotics on VAP prevention and only in the trials that used vancomycin combined with other antimicrobial agents, a significant VAP reduction was found.
Although at these doses VPA did not induce growth inhibition as single agents, a significant synergistic antitumor effect was still demonstrated in combination with 5′-DFUR, suggesting a specific mechanism of interaction [ 22].
1 While there have been advances in therapeutic options for those with advanced (stage III/IV) non-small-cell lung cancer (NSCLC), particularly for subgroups of patients who qualify for treatment with newer targeted agents, a significant unmet medical need remains.
When Gd-DTPA was used as contrast agent, a significant inverse correlation was found between Ktrans and IFP [ 28].
Of particular interest, for the first time with a new agent, a significant reduction in the overall death rate was noted using ticagrelor in place of clopidogrel.
A stratified analysis on nephrotoxic agents (aminoglycosides, glycopeptides and iodinated contrast agents) showed a significant association between renal impairment and IV colistin (OR 2.79, 95%% CI [1.23; 6.32], p = 0.01).
Thus, we should keep in mind that exposure of gadolinium-based contrast agents is a significant risk factor for NSF in patients with kidney disorders [ 15- 17].
Gemcitabine, both as a single agent and in combination with cisplatin or other agents achieves a significant response rate in NSCLC, head and neck carcinoma, pancreatic, breast and gynaecologic cancer (Carmichael, 1998).
