Sentence examples for agent with substantial from inspiring English sources

The CDC guideline for hand hygiene describes chlorhexidine gluconate as an agent with "substantial residual activity".

In this initial proof-of-concept study, we used a clinical gadolinium agent and a manganese chloride based agent with substantial differences in r1 and r2 (Figs. 1 and 3).

Nonsteroidal anti-inflammatory drugs (NSAIDs) are highly effective in treating the pain and inflammation associated with osteoarthritis and rheumatoid arthritis, but it is well recognized that these agents are associated with substantial gastrointestinal toxicity.

Studies that included subgroup analyses of Hispanic patients have shown that treatment with RAAS inhibitors in combination with other antihypertensive agents is associated with substantial BP lowering; however, more data are needed to determine whether RAAS-based treatment regimens improve cardiovascular outcomes in this growing patient population.

Furthermore, weekly administration allows maintenance of the activity of important cytotoxic agents such as taxanes and platinum salts with substantial decrease in toxicity.

Acute febrile illness (AFI) is associated with substantial morbidity and mortality worldwide, yet an etiologic agent is often not identified.

A delay in approval of an agent with even modest activity can cause substantial loss of potential years of life [ 4].

Older patients, or those with substantial comorbidities, will usually respond well to combinations of a β-lactam agent (such as high-dose amoxicillin/clavulanate) plus a macrolide.

While more and more patients are now being treated with chemotherapy in combination with targeted agents, a substantial number does not receive these novel substances, highlighting the importance of this question.

In a few Commonwealth countries, such as India and Pakistan, ICI associate companies with substantial local shareholdings have come under new ICI management, and they act as agents for Zeneca, a transitional arrangement that poses no serious problems.

However, this has to be viewed in the context of the cost associated with the agent, which is substantial.