The primary end point of the study was the overall survival time of patients who were treated with anticancer agents selected by DST.
Of the agents selected by the Phase I/II Committee, 23 are currently undergoing Phase I evaluation (ie trials are either open or planned), 36 did not progress beyond Phase I, and 30 proceeded to further clinical investigation.
To verify the hypothesis that chemotherapy with optimised combinations of anticancer agents could improve the survival of patients with GM, we performed a clinical trial of chemotherapy with agents prospectively selected by the FCM assay for each patient ('individualised chemotherapy').
The agents were selected by the sheer number of columns in which they have been mentioned.
(2) The polypill scenarios simulate the situation in which all eligible individuals, not yet treated with statins or antihypertensive agents, and selected by 'opportunistic screening', are offered lifelong medication.
This was a multi-institutional study conducted at Chiba University Hospital and Chiba Cancer Center Hospital to test the hypothesis that optimised combinations of anticancer agents prospectively selected by DST could improve the survival of patients with GM.
We demonstrated, in the present study, that the chemotherapy with agents prospectively selected by DST for each patient (individualised chemotherapy) was associated with favourable survival time in patients with GM.
The contrast agent dose was selected by estimating signal enhancement during the course of SS-MRA acquisition based on a biexponential approximation of contrast agent concentration determined in a previous study [25] for a range of doses.
The agent selects the most appropriate priority rule according to the shop conditions in real time, while simulated environment performs scheduling activities using the rule selected by the agent.
The intervention process, detailed by Figure 3, shows the main agents that are responsible for determining the intervention (the Intervention agent), selecting the correct profile (Profile agent) and putting forward the intervention to the person (the Interface agent).
