Recent studies indicated that second-line chemotherapy with docetaxel weekly as a single-agent regimen for pretreated non-small cell lung cancer was well tolerant and had an acceptable response rate and a reasonable median survival time about 26.1 weeks [ 7, 11, 12].
In these cases, standard treatment consists of single-agent regimens for palliation and disease control.
Patients with TTP under first-line chemotherapy ⩽6 months and treated with second-line chemotherapy had a median survival time since the starting date of the second-line therapy of 11 months, which represents the best median OS of active first-line triple-agents regimens for metastatic gastric cancer (Wagner et al, 2006).
Three-month PFS rate was 34.6%9595% CI 16 51) with combination and 27.6% (13 44) for single-agent regimen in the overall cohort; it was 50%9595% CI 0.19 0.81) with the combination vs 15% (0 51) with selumetinib alone in the leiomyosarcoma cohort.
These were references to Ms. Atkins's background, to her attempts to trace missing agents, to the training regimen for agents and to Ms. Atkins's retirement.
Cisplatin was the most active single-agent regimen.
In summary, notwithstanding the advent of novel immunosuppressive agents, the ideal regimen for the prevention of ABMR phenotypes 1 and 2 in sensitized KTRs remains unknown.
We retrieved all patient records with treatment codes indicating chemotherapy administration or the use of specific agents and regimens for the treatment of CRC during the study period (Supplementary Table 1).
The most common regimen for this agent in solid tumours is 300 mg b.i.d. for 21 consecutive days with 1 week off.
The research was divided into subcategories discussing cytokine-based therapy, immunotherapy, molecularly targeted agents, other novel targeted agents, and combination regimens for malignant melanoma.
Early-onset HC has been linked to toxic effects of chemo-irradiative agents used in the conditioning regimen for HSCT, e.g. cyclophosphamide and busulfan, and usually starts within 48 72 h after their use [ 1, 18].
