When "discontinuation" was defined as a gap of more than 60 days or starting a non-index biologic agent, the proportion of patients that discontinued each subsequent-line anti-TNF therapy was greater than the proportion that discontinued the respective first-line anti-TNF treatment during the 1-year follow-up period (Table 4).
dicentrarchi vaccine on the basis of three of its main components: antigenic dose, concentration of inactivating agent and proportion of adjuvant in the emulsion, and determined the effect of each factor on protection against the parasite and on antibody production.
Cryptococcus has emerged as the dominant causative agent, the proportion of meningitis due to TB is increasing, and the spectrum of bacterial meningitis has been markedly altered.
Thus, in order to compare all agents we calculated the NCB for each one of the 1000 simulations and subsequently we calculated for each agent the proportion of the simulated trials in which each agent had the highest NCB across a range of RBAT values.
With the use of modern potent agents, the proportion of patients suffering from skeletal-related events (SREs) has been reduced by 30 50% and this reduction has resulted in significant and clinically important benefits in quality of life and preserved function (Coleman, 2004).
Online appendix table 2 gives time of exposure to the glucose-lowering agents and proportions of patients changing treatment, in each group.
For second-generation agents, the proportions with non-SMI diagnoses were similar, although the number of people with a record of dementia was highest for quetiapine (26% of prescriptions).
Factorial experimental design was adopted in this investigation to assess the combined effects of the following factors on fluidity, rheological properties, induced bleeding and compressive strength: water/binder ratio (W/B), dosage of superplasticiser (SP), dosage of viscosity agent (VA), and proportion of limestone powder as replacement of cement (LSP).
PMMA powders were used as the pore-forming agent and the proportion of fine to coarse particles was adjusted to control the pore morphology of the alumina tubes.
It is now well-accepted that HPV represents an etiologic agent in a proportion of OPSCCs, and it has been hypothesized that the driving force behind the rising incidence of OPSCC in the United States is an increase in HPV-related malignancies.
