The PC-SAFT Equation of State is applied here to study polymer – blowing agent phase equilibrium in various systems of industrial interest.
In a recent single agent Phase II trial, PKC412 failed to achieve a single complete remission (CR).
Two of the most active agents in single agent phase II trials are cisplatin and 5-fluorouracil (5-FU) (Alberts et al, 1992; Bleiberg et al, 1997).
Because tosedostat had also reached the MTD as determined in the single agent Phase I study, further dose escalations were not indicated (Reid et al, 2009).
The authors of this later report did not find any correlation between the efficacy and the dose received by patients in targeted agent phase I trials.
The description includes trial name, sponsor, name of agent, phase of trial, inclusion and exclusion criteria, primary and secondary outcomes, number of participants, duration of trial, and location of trial sites.
Indeed, in the single agent phase I study of RO4929097, reversible CYP3A4 autoinduction was detected at daily doses above 24 mg in the 3 consecutive days per week schedule (Tolcher et al, 2012).
A single agent phase II study revealed evidence of only weak activity and an acceptable toxicity profile in patients with non-small cell lung cancer (NSCLC), who had received prior treatment with platinum-based chemotherapy (Talbot et al, 2002).
