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Two-thirds of the isolated pathogens were reported as colonizers, 30% as causative agent of infections.
This is especially a problem when trying to accurately genotype the causative agent of infections from WGS obtained directly from clinical specimens.
The closely related NiV was subsequently identified as the causative agent of infections in pigs and humans in Malaysia in 1998-99 [ 4].
MRSA is unquestionably one of the most important nosocomial pathogens worldwide, but recently it is increasingly identified as the etiological agent of infections acquired in community [ 1, 2].
E. coli is the most common etiologic agent of infections caused by Gram-negative bacilli, and these infections routinely are treated with fluoroquinolones, some of the most-frequently prescribed antibiotic classes [ 1].
But on certain occasions, the presence of S. epidermidis as a contaminant of medical devices, or breach of the skin by trauma or inoculation needles, makes it emerge as a causative agent of infections [ 1].
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Brucella suis is also emerging as an agent of infection in cattle, thus extending its opportunities to infect humans.
Fungal diseases of the vulva are common; usually the agent of infection is Candida albicans, a yeastlike fungus.
In practice, this ideal goal is difficult to attain and one must settle for a preferred toxicity towards the agent of infection, i.e. the toxic dose towards the agent of infection must be significantly lower than the toxic dose towards the cells or tissues that they invade.
We determined an agent of infection in 6 of 40 catheters tips that we evaluated (1%5).
We determined no agent of infection in the others 34 catheters.
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