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Are there health effects observed in populations exposed to the agent of concern?
PBPK models represent in quantitative terms the complex physiologic and biochemical processes that affect the absorption, distribution, metabolism, and elimination of the agent of concern.
Videotaping has the advantages of tracing a given individual throughout his/her activities in daily life and observing potential contacts with the agent of concern and the frequency/duration of these contacts.
Observance of health effects in populations exposed to the agent of concern is germane to design future epidemiologic studies that are able to link biomarkers to health effects (Albertini et al., 2006).
(Note that some characterization of the health effects observed in populations exposed to the agent of concern is needed to design a new epidemiologic study that is focused on disease end points. Furthermore, these health effects must be known before biomarkers are used to identify population exposures and assess risk).
Because development of biomarkers suitable to monitor exposure in human populations is essential to human risk and relevance, approaches to develop genomic biomarkers for individuals exposed to a specific agent of concern would provide the necessary advances to develop broad biomarker-based approaches (McHale et al. 2010).
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These emerging contaminants, which have not historically been considered as pollutants, have now become prominent agents of concern to public health specialists and environmental engineers and scientists.
The NIAID National Institute for Allergyy and Infectious Diseases) Biodefense Proteomics program aims to identify targets for potential vaccines, therapeutics, and diagnostics for agents of concern in bioterrorism, including bacterial, parasitic, and viral pathogens.
Observational studies must establish contact frequency, duration, and intensity of exposure agents of concern.
Our framework, shown in Figure 3, includes driving forces; sources of releases of environment agents of concern; concentrations of environmental agents of concern measured or estimated in environmental ambient or exposure media; concentrations of agents of concern in human tissues; and health outcomes (diseases and disorders) in populations.
However, as discussed below, complete exposure assessment to all these chemical and biologic agents of concern is a complex task.
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