This Review summarises the rationale for targeted therapy, challenges in paediatric drug development, unique side-effect profiles of targeted agents, limited data from children treated with targeted agents, and implications of current knowledge and gaps therein.
The different toxicity profiles, responses on imaging, and mechanisms of action of these targeted agents have implications for the way that clinical trials with these agents are conducted.
The table of contents alone is enough to leave a reader sleepless, with headers like "Biological and Toxin Agents," "Military Implications of Genetic Engineering" and "Delivery Systems".
Screening for a sexually transmitted agent has important implications (Duncan et al, 2001), with particular significance for those in long-term monogamous relationships or within groups where lifelong monogamous relationships are more strongly advocated, such as some religious and ethnic minority groups (Elam et al, 1999).
The findings of the cell-autonomous effects of GSNOR deficiency on AGT and cell sensitivity to an alkylating agent might have implications in cancer treatment using chemotherapeutic alkylating agents.
Our data uncovered implication of the enzymes of the respiratory chain in the HNE action; results in contrast with effects of H2O2, a common oxidative agent, point to implication of different metabolic pathways.
The excellent in vitro activity of echinocandins demonstrated against fluconazole-resistant Candida species strains indicates that the echinocandins are very promising as novel antifungal agents with important implications for the treatment of infections by these yeasts (24, 33, 34 ).
Those problems, however, may still apply at an individual agent level and their implications to the pursuit of an ontology centric development process are instructive indeed.
According to Clint Watts, a national security policy expert at the Foreign Policy Research Institute and former FBI special agent, the more frightening implications of this data dump are geopolitical in nature, given the close links between Russia and WikiLeaks and Russia's increasingly adversarial relationship with the West.
Use of probe 4 or a related companion imaging agent could have broad implications for the design of future MDR1 inhibitors.
