Several of these agents exhibited increased selectivity towards Mcm2-7, whereas others had varying specificities against a range of unrelated helicases.
Cells lacking the mitochondrial division component Fis1p, however, were not resistant to these agents, and even exhibited increased sensitivity to CHX, demonstrating that not all mutations permitting mtDNA maintenance by fzo1 ∆ aac2 ∆ cells lead to PDR activation.
Having demonstrated that BD-L was enriched in BRCA1 mutation carriers, we hypothesized that breast cancer cell lines with elevated BD-L values may exhibit increased sensitivity to therapeutic agents that target a dysfunctional BRCA1-associated pathway.
We found that, compared with control-vector-transfected cells, the MCF7RasG12V cells exhibited increased resistance to several chemotherapeutic agents currently used for treating breast cancer patients.
As observed with V158411, the TNBC and ovarian cell lines exhibited increased sensitivity to these two agents compared to the MCF7 and BT474 breast cell lines.
Accordingly, the HOG mutants exhibited increased sensitivity to the polyene class of antifungal agents, such as amphotericin B, but decreased sensitivity to the azole drugs, such as fluconazole and ketoconazole [9].
Analogues of curcumin, which exhibit increased potency, are needed as more effective therapeutic agents for colorectal cancer treatments.
Gd III) agents attached to nanomaterial scaffolds are an attractive alternative because they exhibit increased relaxivity and show efficient cell labeling.
PC3 cells overexpressing Shb exhibited increased rates of apoptosis in the presence of the anti-tumor agent 2-ME.
Recently, we reported that a multivalent Zn-BDPA fluorescent probe exhibited increased selectivity for PS-rich membranes and was an effective imaging agent in cell culture and three animal models of cell death.
Interestingly, the cytotoxic agent Ecteinascidin 743 (ET-743), which has activity against soft tissue sarcomas, was found to exhibit increased toxicity in cells with defective NHEJ (Damia et al, 2001).
