In addition, sorafenib (at the standard dose of 400 mg BID) is tolerated poorly by ovarian cancer patients, even when used as a single agent; difficulties in adding sorafenib to combination chemotherapy have also been demonstrated in other diseases 22, 23.
Four save files are available to track the player's progress through the game's twenty missions, each of which may be played on "Agent", "Secret Agent", or "00-Agent" difficulty settings.
Yet even after two decades as a novelist she clearly remembers some of the downsides of acting: getting and keeping agents, difficulties sustaining a career.
A disenchanted C.I.A. agent has difficulties and gets caught up in the agency's affairs.
The averaging system is so complicated that even many insurance agents have difficulty explaining it.
It seems our nation's capital is giving TSA agents some difficulty.
On December 25, a suspected chemical weapons attack in Moadamiya drove civilians to the local hospital with symptoms consistent with exposure to toxic agents, including difficulty in breathing, bloody frothing at the mouth, muscular contractions and involuntary urination and defecation.
Last fall, Paul Stephens reported for Washington Monthly on complaints about local students being displaced, accounts of unscrupulous recruiting agents, and difficulties experienced by some non-native English speakers in classes that lean heavily on language skills.
Replication-blocking lesions induced by reactive metabolites, such as aldehydes, and exogenous DNA damaging agents aggravate difficulties intrinsic to the replication program.
Some important considerations for treatment of neurodegenerative diseases are the impermeability of the blood-brain barrier to many therapeutic agents and difficulties in reversing brain damage that has already occurred.
The main disadvantage of topical agents is a difficulty to supply active agents to affected area, especially during deep skin infections [ 12, 13].
