Sentence examples similar to agent demonstrating substantial from inspiring English sources

Ifosfamide, an oxazophosphorine alkylating agent like cyclophosphamide, has demonstrated substantial activity in advanced breast cancer (Ahmann et al, 1974).

The biologic agents, particularly tumour necrosis factor blockers, have demonstrated substantial responses for many, but not all, patients.

More recently, clinical trials investigating the efficacy and safety of anti-vascular endothelial growth factor agents in patients with myopic CNV have demonstrated substantial visual acuity gains and quality of life increases compared with photodynamic therapy.

Results from nonrandomized studies with different chemotherapeutic agents or combination regimens given preoperatively demonstrated substantial clinical response rates but low pathologic tumor response rates.

Viral receptor binding and internalization studies that used recombinant HAdV-14p1 fiber regions containing the 2-aa deletion did not demonstrate substantial phenotypic differences between the new agent and the prototype virus (12 ).

Recent randomised clinical studies have demonstrated substantial benefits for combinations of targeted agents such as endocrine therapy and mTOR inhibitors in ER+ve MBC [ 72] or horizontal dual HER-receptor blockade [ 289- 292].

Furthermore, they continued to demonstrate substantial improvement in reducing unemployment levels.

Mice carrying FVII+/− genotype have demonstrated substantial phenotypic changes such as prolonged PT in plasma.

We found that FR patterns in PMd demonstrated substantial temporal variation during the decision-formation process.

Fueled with the most reactive isotopes of hydrogen, those tokamaks demonstrated substantial release of fusion energy.

Bilingual education programs, the report concludes, "have demonstrated substantial effectiveness in developing the English language proficiency" of immigrants.