It is clear, however, that in addition to ROS, a much broader range of extrinsic and intrinsic sources, such as UV irradiation, alkylating agents, telomere attrition, and DNA replication errors, can also infringe upon genomic integrity [ 2].
Further investigation is warranted to find out the factors downstream of DNA-PKcs which are required for external agent induced telomere attrition in human cells.
Therefore, our approach was to test whether experimental exposure to actual infectious agents causes telomere attrition using wild house mice.
ABM can be used to explore goal directed behaviors such as completing a task in robotic autonomy [18] or to study emergent macro-level outcomes that arise from micro-level agent interactions such us workforce attrition in STEM organizations [19].
We experimentally tested whether repeated exposure to an infectious agent, Salmonella enterica, causes telomere attrition in wild-derived house mice (Mus musculus musculus).
The methodology for this study comprises an empirically validated NETLOGO agent-based model of worker attrition using OPM data sets for high-density STEM organizations.
In recent years, a substantial body of systems and agent-based modeling research on worker attrition and group-oriented culture has focused on linkages to organizational performance and employee satisfaction at large [3, 4, 5, 6, 7, 8].
Overall, 244 compounds were assessed in the decade of 2002 through 2012 and one was approved for marketing; excluding the 14 compounds currently in Phase 3, the success rate for advancing agents for regulatory approval is 0.4%99.6%6% attrition).
The following agents belong to the intrinsic category: parafunctions (attrition, abfraction), gastroesophageal reflux (erosion), eating disorders (erosion), bruxism (attrition), and abnormal occlusal or biomechanical loads/forces (abfraction) [ 4, 13, 17].
