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Multiple candidate agents could be tested in the protocolized AKI management plus therapeutic agent arm of the study.
The ORR was only 16% and the duration of response was 8 months in the single agent arm and 5 months for the combination arm.
Interestingly, this did not translate into an improved OS, a factor the authors attributed to the extensive post-study treatment in the single agent arm (Table 1).
The vehicle arm and the celecoxib single agent arm showed time to progression of 7 (6–10) days, n=5 vs 11.5 (10 12) days, n=5, respectively.
The main problem was the fact that only 31.1% of patients in the combined agent arm and 42.2% of the patients in the EMP alone arm were able to receive two or more cycles.
A summary of these trials split in this way is given in Table 5-wrap> and the meta-anaylsis plots are given in Figure 3 The hazard ratio for overall survival when a higher platinum dose was used in the single agent arm was 1.01 (95% CI 0.79 1.28; P=0.79 1.28
Similar(52)
Five years ago, he survived an assassination attempt by an agent armed with two poison-tipped pens and a torch that fired bullets.
Its job is to search an infinity of faces for those presenting some sort of imminent threat with techniques more sophisticated than a seated agent armed with a ballpoint pen staring briefly at a passport photo and back at a boarding pass.
There's a great deal of depth on the 40-man as it stands, but a wealth of free agent arms still looking for jobs could lead to another bullpen addition if the price is right.
A prime example occurred in 2002, when the FBI dispatched a special agent, armed with a camera, to a peace rally to search for terrorism suspects who might happen to be there, just to "see what they are doing".
This flatter world is a powerful selective agent armed with big challenges and opportunities.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com