For certain newer agents, such as filoviruses and Nipah virus, current evidence is insufficient to state whether after a generalized release of an aerosolized agent, animal infection would precede that in humans.
After administration of some anaesthetic agents, especially injectable agents, animals may become ataxic, show poor coordination and poor reflex response, especially on the back limbs during the recovery, and therefore, it is important that they are monitored closely until they gain normal behaviour.
Experimental designs, therapeutic agents, animals, or cell types in the previous studies and the present study were different.
For experiments involving intravitreal delivery of exogenous agents, animals that developed complications from the injection procedure (e.g., ocular infection, inflammation) were excluded from the analysis.
Two hours after the administration of the test agents, animals were challenged by painting the outer and inner surface of the left ear with DNFB.
The underlying model of the agent-animals (voles) was unchanged in all scenarios, thus the emergent changes in population dynamic patterns originated from changes in predator composition and landscape fragmentation, only, leading to variations in both intra- and interspecific interactions.
For this study, a 10 × 10 km natural landscape (Fig. 2) was used, comprised of patches of optimal vole habitat, interspersed in a matrix, allowing the agent-animals to move through freely, but restricting reproduction and long-term survival to habitat patches.
For pharmaceutical agents, animal studies guide development before human clinical trials can occur.
iNOS inhibition in AHF is controversial, fuelled by conflicting results from studies using varieties of pharmacological agents, animal models and temporal protocols.
Pasteur chose to conduct his experiments using rabbits and transmitted the infectious agent from animal to animal by intracerebral inoculations until he obtained a stable preparation.
Among the physical agents that give rise to cancer, radiant energy is the main tumour-inducing agent in animals, including humans.
