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First, we evaluated the correlation between myocardial lipofuscin levels and ageing in normal human hearts.
The distribution of fat and non-fat marrow predominantly depends on ageing in normal subjects.
In agreement with previous studies (Hastie et al, 1990; Gertler et al, 2004), we found that telomere length decreased with ageing in normal mucosa, but not in tumours.
There is a steep and linear decline of normal early diastolic velocity with ageing in normal people, from 16 cm/s at the age of 20 years to 6 cm/s at 80 years.
An alternative to the study of whole body ageing in normal humans is the study of progeroid syndromes whose phenotypes show specific characteristics of ageing (Hofer et al. 2005; Kudlow et al. 2007).
P16ink4a is a CDK inhibitor (Dimri et al, 1995; Campisi, 2005), the expression of which is upregulated in cellular senescence and ageing in normal tissues (Krishnamurthy et al, 2004; McGlynn et al, 2009).
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The chemical composition of the interface layer changes towards SiO2 and its thickness increases with aging in normal ambient conditions.
Romero, R. et al. The maternal plasma proteome changes as a function of gestational age in normal pregnancy: a longitudinal study.
This study aimed to investigate alignment based on age in normal knees and alignment based on deformity in osteoarthritis (OA) knees using detailed radiographic parameters.
In humans, epigenetic changes correlate with older age in normal individuals and are a hallmark of patients with progeria syndrome; however, the significance of epigenetics in regulating the rate of aging is not well understood.
The heart rate decreased linearly with age in normal control subjects (r = -.47, P less than.01).
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