The phrase "age rage" is correct and usable in written English.
It can be used to describe feelings of frustration or anger related to aging or generational differences.
Example: "As I approached my forties, I started to experience a sense of age rage, feeling overwhelmed by the changes in my body and life."
Alternatives: "midlife crisis" or "generational frustration".
The advanced glycation end products (AGEs -receptor for AGEs -receptors activity are implicated in diabetic vascular complications.
Advanced glycation end-products (AGE) and the receptor for AGE (RAGE) have been linked to numerous diabetic vascular complications.
AGE can bind to the receptor for AGE (RAGE) on the membrane to elevate ROS productions through activation of NADPH oxidase (Calcutt et al. 2009).
AGEs can also activate the receptor for AGE (RAGE) and thereby induce cardiovascular dysfunction [ 12].
The receptor for AGE (RAGE) is the most studied receptor for AGEs.
Receptor for AGE (RAGE) is expressed in macrophages, ECs, and VSMCs [ 104], and AGE-RAGE interaction induces signaling pathways associated with increased ROS production and activation of inflammatory response in vascular cells [ 105].
Therefore, the AGE-RAGE-induced oxidative stress generation could further potentiate the harmful effects of AGEs via RAGE overexpression.
The AGE/sRAGE ratio has been proposed as an improved biomarker for the AGE-RAGE-sRAGE axis [ 27].
Inhibition of AGE-RAGE axis by several PPAR-γ agonists has shown positive results in ameliorating cardio-metabolic disease conditions.
AGE-RAGE interaction mediated oxidative stress and inflammation is the key mechanism involved in the pathogenesis of cardiovascular disease in diabetes.
Its inhibitory effects on the AGE-RAGE axis also make it a potential treatment for diabetic vascular diseases aside from being a preventive drug for the metabolic syndrome.
