Sentence examples for age of tissues from inspiring English sources
The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse.
Among the factors involved included the genotype of plants, types and age of tissues used, the Agrobacterium strains and binary vectors used, and the various tissue culture conditions [ 6].
DNA methylation (DNAm) levels can be used to predict the chronological age of tissues; however, the characteristics of DNAm age signatures in normal and cancer tissues are not well studied using multiple studies.
The correlation between the actual ages of the combined normal samples and their predicted ages using the model was highly significant (R = 0.91, P = 0.002 from 10,000 random selection tests using all loci in the platform; Figure 5A), which indicates that the DNAm levels of the age-associated signature sites can be used to predict the age of tissues, regardless of tissue type.
In aging research, morphological age of tissue helps to characterize the effects of aging on different individuals.
The outcomes from each age were markedly different, with E13.5 being adopted as the standard age of tissue source.
In fact, the epigenetic clock has already been used to predict the epigenetic age of tissue samples (Horvath, 2013).
Objectively measuring the age of tissue such as blood poses a significant methodological and conceptual challenge since it is debatable whether known causes of cellular senescence such as telomere length represent tissue, much less organismal aging [ 7- 10].
Previously it has been shown that regardless of fixation time or age of tissue blocks, quantitative real-time PCR data for two miRs (miR-16 and miR-122) can be generated from FFPE tissues from different sites [ 14].
The fraction of reads of plastid and mitochondrial genome origin obtained from such a library can vary depending on the age of tissue, DNA extraction method, relative size of the organelle and nuclear genomes, and species [ 34].
Third, the aging of cells in the test tube is not necessarily the same as the aging of tissues in the body.
