In this age of algorithmic aggregation, we also salute titles that have a decidedly human touch.
If protein aggregation is central to bacterial aging, the process of aggregation should also be flexible and responsive to environmental stimuli.
As described previously, expression of the near-threshold yellow fluorescent protein (YFP -tagged polYFP -taggedexpolyglutamine40-YFP (Q40) in musclexpansionf C. elegans shows a striking age-dependent onset of aggregation, regulated by heat shock factor 1 (HSF1) and the insulin signaling pathway [ 25, 26, 67].
Families showing two or more of these clinical criteria (ie, early age of cancer onset, aggregation of tumours in a sibship, 'verticality', proximal location in the large bowel, multiple primaries) were contacted and the pedigrees extended to second- and third-degree relatives.
Importantly, we did not observe any difference in the extent of age-associated aggregation of YFP polyQ35 in hif 1 ia04) mutant animals compared to wild-type controls (Fig. 4B).
Another positive associations were found between age of onset and familial aggregation of disease: smoking and younger age of onset, smoking and occurrence of pustular psoriasis, nail involvement and arthropatic psoriasis, nail involvement and more severe course of psoriasis.
Another positive associations were found between age of onset and familial aggregation of disease: smoking and younger age of onset, smoking and occurrence of pustular psoriasis, nail involvement and arthropatic psoriasis, nail involvement and more severe course of psoriasis vulgaris.
We presume that cells with these aggregates represent [PSI+] cells in the originating culture, and that some effect of a particular Ssa6p and Ssa7p activity that leads to prion instability might eventually cause this type of aggregation as cells age.
Both age of onset and protein-aggregation propensity are strongly associated with the length of the polyQ expansion, further suggesting that aggregate formation forms the basis of disease (Gusella and MacDonald, 2000; Wellington et al., 2000).
As in the human diseases, the polyglutamine-YFP peptides show age-dependent aggregation, with the rapidity of aggregation and cytotoxicity correlating strongly with the length of the polyglutamine repeat.
