Sentence examples for age modulation from inspiring English sources

The observed deficits in learning performance and the lack of significant age modulation of the genetic association suggest a more general genetic effect.

Despite these interspecies differences, the observed associations between telomere length and attrition suggest there may be additional information to be learned by understanding the physiologic contributors to telomere attrition that overlap with aging modulation.

No matter whether mitochondrial DNA damage is involved or electron transport chain damage is responsible for aging, modulation of cellular signal response to stress or activation of redox-sensitive transcriptional factors by age-related oxidative stress causes the upregulation of proinflammatory gene expression, finally leading to an increase in the ROS levels [ 146].

This hub interacted with two classes of miRNAs, one with age-constant expression and the other with age-related modulation.

Evidence in support of this idea would provide further justification for analysis of the role of ATF4 in postponement of aging, while discovery of interventions that slow aging without modulation of ATF4 are also likely to be of great interest.

As the use of age-weighting in the calculation of DALYs is controversial due to preferential weights given to young adults as compared with children and elderly, we calculated DALYs without age-weighting in which the value of the age-weighting modulation factor K = 0 and C and β become not applicable.

Finally, on the basis of the network functions analyses, the miRNAs with age-related modulation in expression as well as the aging-diminished miRNAs all had network functions in both inflammatory disease and inflammatory response.

Inflammatory disease and the inflammatory response were the common network functions associated with miRNAs that showed age-related modulation (either up- or down-regulation in adults) and aging-related diminution.

Our results provide insights into a novel PVF2-mediated mechanism for age-related modulation of intestinal stem populations and suggest that oxidative stress is likely to contribute significantly to age-related changes in intestinal stem cell biology.

Kusumbe, A. P. et al. Age-dependent modulation of vascular niches for haematopoietic stem cells.

Age-associated modulation of these effector systems will be discussed in the context of the immune deficiency of T-cells.